The method of personalized nutrition considering genetically determined factors

Background: Despite the great successes of modern dietology, there is currently no way of personalized nutrition, taking into account all genetic deterministic factors.

Purpose: To develop a way to personalize nutrition, taking into account genetically determined factors.

Materials and Methods: The object of research is personalized eating behavior. Intestinal microbial enterotypes are identified using polymerase chain reaction. Blood groups and Rh factors are determined in the agglutination test using coliclones or standard hemagglutinating sera.

Results: A highly effective method of personifying nutrition, taking into account blood groups (0 (I), 0A (II), 0B (III), AB (IV)), blood Rh factor (Rh+ and Rh–), gender (α and β) and enterotypes (enterotype No.1: Bacteroides, enterotype No.2: Prevotella and enterotype No.3: Ruminococcus), which allows for precise and maximally personal regulation of human eating behavior. The method of personifying nutrition, taking into account genetically determined factors, involves the selection of food products based on genetically determined factors: the immune system of the blood — blood groups and Rh factor, enterotypes, as well as gender, while food products are selected in stages, according to the following algorithm: (1) determine blood group by the amount of agglutinins (α and β) in plasma, agglutinogens (A and B) in erythrocytes and find the Rh factor; (2) determine the compatibility of food components with the components of the blood immune system by the isoagglutination reaction: α and β-agglutinins, A- and B-agglutinogens, as well as Rh+ and Rh– Rh-factors; (3) remove food products from the diet, the components of which cause an agglutination reaction with the components of the blood immune system; (4) the prevailing enterotype is determined by the method of polymerase chain reaction: enterotype No.1 bacteroids — Bacteroides, enterotype No.2 of Prevotella — Prevotella or enterotype No.3 of ruminococcus — Ruminococcus; (5) emove from the diet hard-to-digest foodstuffs, the established enterotype: for enterotype No.1 with a universal protein-fat-carbohydrate diet, you can not remove food products, for enterotype No.2 with a carbohydrate diet, reduce the amount of foods with a high content of proteins and fats, for enterotype No.3 with a carbohydrate-fat diet reduce the amount of foods high in protein; (6) remove food products from the diet, the components of which cause inhibition of the synthesis of sex hormones: for women — progestogens and estrogens, for men — androgens.

Conclusion: We have proposed a highly effective way to personalize nutrition, taking into account blood groups (0(I), 0A(II), 0B(III), AB(IV)), blood Rh factor (Rh+ and Rh–), gender (α and β) and enterotypes (enterotype No.1: bacteroides (Bacteroides), enterotype No.2: Prevotella (Prevotella) and enterotype No.3: ruminococci (Ruminococcus)), which allows for precise and most personal regulation of human eating behavior.

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