Способ персонификации питания с учетом генетически детерминированных факторов

Введение: Несмотря на большие успехи современной диетологии в настоящее время отсутствует способ персонифицированного питания с учётом всех генетических детерменированных факторов.

Цель: Разработать способ персонификации питания с учетом генетически детерминированных факторов.

Материалы и методы: Объект исследований — персонифицированное пищевое поведение. Кишечные микробные энтеротипы идентифицируют с применением полимеразной цепной реакции. Группы крови и резус факторы определяют в реакции агглютинации при помощи цоликлонов или стандартных гемагглютинирующих сывороток.

Результаты: Предложен высокоэффективный способ персонификации питания с учетом групп крови (0(I), 0A(II), 0B(III), AB(IV)), резус-фактора крови (Rh+ и Rh–), гендерной принадлежности (α и β) и энтеротипов (энтеротип № 1: бактероиды (Bacteroides), энтеротип № 2: превотелла (Prevotella) и энтеротип № 3: руминококки (Ruminococcus)), позволяющий осуществлять точную и максимально персональную регуляцию пищевого поведения человека. Cпособ персонификации питания с учетом генетически детерминированных факторов предполагает подбор продуктов питания на основе генетически детерминированных факторах: иммунной системы крови — группы крови и резус-фактор, энтеротипах, а также гендерной принадлежности, при этом пищевые продукты подбирают поэтапно, согласно следующему алгоритму: 1) определяют группу крови по количеству агглютининов (α и β) в плазме, агглютиногенов (А и В) в эритроцитах и находят резус-фактор; 2) определяют по реакции изоагглютинации совместимость компонентов продуктов питания с компонентами иммунной системы крови: α и β-агглютининов, А- и В-агглютиногенов, а также Rh+ и Rh– резус-фактора; 3) удаляют из рациона питания пищевые продукты, компоненты которых вызывают реакцию агглютинацию с компонентами иммунной системы крови; 4) определяют методом полимеразной цепной реакции преволирующий энтеротип: энтеротип № 1 бактероиды — Bacteroides, энтеротип № 2 превотелла — Prevotella или энтеротип № 3 руминококки — Ruminococcus; 5) удаляют из рациона продукты питания трудноусвояемые, установленному энтеротипу: для энтеротипа №1 с универсальной белково-жиро-углеводной диетой можно не удалять пищевые продукты, для энтеротипа № 2 с углеводной диетой понижают количество пищевые продукты с большим содержанием белков и жиров, для энтеротип № 3 с углеводно-жировой диетой понижают количество пищевые продукты с большим содержанием белков; 6) удаляют из рациона питания пищевые продукты, компоненты которых вызывают ингибирования синтеза половых гормонов: для женщин — прогестогены и эстрогены, для мужчин — андрогены.

Заключение: Нами предложен высокоэффективный способ персонификации питания с учетом групп крови (0(I), 0A(II), 0B(III), AB(IV)), резус-фактора крови (Rh+ и Rh–), гендерной принадлежности (α и β) и энтеротипов (энтеротип №1: бактероиды (Bacteroides), энтеротип №2: превотелла (Prevotella) и энтеротип №3: руминококки (Ruminococcus)), позволяющий осуществлять точную и максимально персональную регуляцию пищевого поведения человека.

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